Material safety data sheet spironolactone

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Spironolactone is a potassium-sparing diuretic medication used to treat high blood pressure and heart failure.

This document provides information on the safety and handling precautions for spironolactone.

Description and Properties

Description and Properties

Spironolactone is a prescription medication that belongs to the class of potassium-sparing diuretics. It is primarily used to treat conditions such as high blood pressure, heart failure, and edema (fluid retention) caused by various medical conditions.

Key properties of Spironolactone:

Property Description
Solubility Sparingly soluble in water, soluble in alcohol.
Molecular Formula C24H32O4S
Molecular Weight 416.57 g/mol
Appearance White to off-white, crystalline powder

Description and Properties

Spironolactone is a medication that belongs to a class of drugs known as aldosterone receptor antagonists. It is primarily used to treat conditions such as high blood pressure, heart failure, and edema (fluid retention).


  • Chemical Name: 17-hydroxy-7α-mercapto-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactone acetate
  • Molecular Formula: C24H32O4S
  • Molecular Weight: 416.57 g/mol
  • Appearance: White to off-white crystalline powder
  • Solubility: Sparingly soluble in water; soluble in acetone, ethanol, and methanol

Spironolactone works by blocking the effects of aldosterone, a hormone that regulates sodium and water balance in the body. It acts as a diuretic to increase urine production and reduce fluid retention, thus helping to lower blood pressure and alleviate symptoms of heart failure and edema.

Handling and Storage

Spironolactone should be handled with care to avoid any accidental exposure. Wear appropriate personal protective equipment such as gloves and safety goggles when handling the substance.

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Store spironolactone in a cool, dry place away from direct sunlight and sources of heat. Keep the container tightly closed when not in use to prevent contamination and moisture ingress.

Do not store spironolactone near incompatible materials or chemicals to avoid any potential reactions. Follow all local regulations and guidelines for the proper storage and handling of this substance.

Handling Precautions 1. Avoid inhalation, ingestion, or skin contact with spironolactone.
Storage Recommendations 2. Store in a well-ventilated area with adequate ventilation.
Storage Conditions 3. Keep containers tightly closed when not in use.

Exposure Controls and Personal Protection

When handling spironolactone, it is important to follow the necessary safety precautions to prevent exposure and minimize risks. The following exposure controls and personal protection measures should be implemented:

Engineering Controls: Ensure adequate ventilation in the working area to minimize exposure to spironolactone vapors and dust. Use local exhaust ventilation if necessary.
Personal Protective Equipment (PPE): Wear suitable protective clothing, gloves, and eye protection when handling spironolactone. Use respiratory protection if ventilation is inadequate.
Eye Protection: Wear safety goggles or a face shield to protect your eyes from contact with spironolactone.
Skin Protection: Use chemical-resistant gloves and protective clothing to prevent skin contact with spironolactone. Wash hands and any exposed skin thoroughly after handling.
Respiratory Protection: If ventilation is inadequate or if there is a risk of inhalation exposure, use a NIOSH-approved respirator with appropriate cartridges for organic vapors.

By following these exposure controls and personal protection measures, you can help ensure a safe working environment when handling spironolactone.

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First Aid Measures

In case of contact with eyes:

  • Rinse immediately with plenty of water for at least 15 minutes. Remove contact lenses if present and easy to do. Continue rinsing.
  • If eye irritation persists, get medical advice/attention.

In case of skin contact:

  • Wash off with soap and water. If skin irritation occurs, seek medical advice/attention.

If swallowed:

  • Do not induce vomiting. Rinse mouth and seek medical advice/attention immediately.

If inhaled:

  • Remove person to fresh air and keep comfortable for breathing. Seek medical advice/attention if breathing difficulties occur.

In case of accidental exposure or if you feel unwell, seek medical advice immediately and show the product label or safety data sheet.

Disposal Considerations

Spironolactone should be disposed of in accordance with local regulations. Do not dispose of spironolactone in household waste or down the drain. Contact your local waste management facility or regulatory agency for proper disposal methods.

Unused or expired spironolactone should be returned to a pharmacy or healthcare provider for proper disposal. Do not flush medications down the toilet unless instructed to do so.

It is important to follow proper disposal procedures to prevent environmental contamination and protect human health. Improper disposal of pharmaceuticals can have detrimental effects on aquatic ecosystems and wildlife.

Additional Information

Here are some extra details about our product that you should know:

Manufacturer: Our company
Product Code: 12345
Storage Conditions: Store in a cool, dry place away from direct sunlight
Shelf Life: 2 years
Regulatory Information: This product complies with all applicable regulations

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